Manish V. Bais

This study shows that LOXL2 deletion in mice worsens post-traumatic knee osteoarthritis and pain, resembling human OA, and that LOXL2 injection improves joint function and reduces pain.

This study shows that dietary serine restriction alters H3K27me3 and H3K4me3 histone modifications, reducing tumor growth and plasticity in head and neck cancer.

This paper develops a humanized mouse model of oral squamous cell carcinoma to study resistance to anti-PD1 immunotherapy and identifies mechanisms of resistance.

This study identifies a unique transcriptomic signature in the temporomandibular joint (TMJ) compared to the knee, highlighting its vulnerability to osteoarthritis and validating an in vitro model.

This study investigates the role of LOXL2 in TMJ osteoarthritis, showing that its deletion worsens the condition while overexpression protects against chondrocyte apoptosis and inflammation.

This study shows LSD1 inhibition enhances antitumor immunity in HNSCC by upregulating MHC-I and activating the IFNγ-CXCL9-CXCR3 axis through dendritic cells and CD8+ T cells.