Itaconate promotes the differentiation of murine stress erythroid progenitors by increasing Nrf2 activity.
Baiye Ruan, Yuanting Chen, Sara G. Trimidal, Meghna Chakraborty, Aashka Shah, Hangdi Gong, Imhoi Koo, Jingwei Cai, John Mcguigan, Molly A. Hall, Andrew D. Patterson, K. Sandeep Prabhu, Robert F. Paulson
The paper shows itaconate promotes differentiation of stress erythroid progenitors by increasing Nrf2 activity through anti-inflammatory signaling.
Blood Red Cells & Iron · Feb 27, 2025Peer-reviewedDevelopmental Biology