Andrew D. Patterson

The paper identifies glycine-conjugated indole-3-carboxylates as AHR ligands, showing human-specific activation and microbial/host-mediated metabolism.

This study identifies a fatty acid-driven neutrophil-adenosine axis that promotes immunosuppression in colorectal cancer and shows that targeting adenosine receptors can enhance immunotherapy responses.

The paper systematically extracts and catalogs acylcarnitine metabolites from multiple repositories, identifying previously unknown carnitines and providing a resource for further metabolic research.

The paper identifies microbial bile acid conjugation as a drug-activating function for 5-ASA, revealing its therapeutic relevance through metabolomics analysis.

This study shows glyphosate exposure increases blood pressure through gut microbiota-mediated disruption of FXR-signaling and shikimic acid accumulation.

The paper identifies fedratinib as a drug that increases endoplasmic reticulum-mitochondria contact sites by inhibiting BRD4, revealing a novel epigenetic pathway linking ERMCS to cellular metabolism.

The paper introduces microbiomeMASST, a metadata network graph linking metabolites across datasets, enabling cross-study analysis of microbial metabolites and their biological context.

This study shows maternal diet affects offspring microbiota and health through goblet cells, leading to long-term disease susceptibility.

This study shows that the gut microbiome affects methotrexate pharmacology in mice and contributes to interindividual variation in drug metabolism and treatment outcomes.

The paper shows itaconate promotes differentiation of stress erythroid progenitors by increasing Nrf2 activity through anti-inflammatory signaling.

This study identifies a nitric oxide-dependent metabolic pathway in stress erythroid progenitors that promotes proliferation and inhibits differentiation during inflammatory anemia.