A genetic bottleneck of mitochondrial DNA during human lymphocyte development
Zhongjie Tang, Zhaolian Lu, Baizhen Chen, Weixing Zhang, Howard Y. Chang, Zheng Hu, Jin Xu
The paper identifies a mitochondrial DNA bottleneck during lymphocyte development, leading to homoplastic mutations despite lower mutational burden.
Molecular Biology and Evolution · Apr 27, 2022Peer-reviewedGenetics