Zhongjie Tang

The paper identifies common evolutionary events leading to fungicide persistence in Cryptococcus neoformans clinical isolates and shows ACO2 deficiency as a key predictor of high persistence.

The paper investigates the reliability of mitochondrial DNA variants as lineage markers, finding that most are pre-existing heteroplasmy rather than de novo mutations, and introduces a score to identify reliable markers.

The paper identifies a mitochondrial DNA bottleneck during lymphocyte development, leading to homoplastic mutations despite lower mutational burden.