Zhaolian Lu

The paper investigates how alternative TSS usage correlates with gene expression and translation efficiency across eukaryotes, revealing its role in regulating protein production.

This study uses lineage tracing and single-cell analysis to show tumor plasticity precedes stable immune evasion, with AP-1 regulating EMT stabilization during immunotherapy.

scPhyloX infers tissue development and tumor evolution dynamics using single-cell phylogenetic trees, revealing novel insights into stem cell overshoot, hematopoietic progenitor clonal expansion, and colorectal tumor subclonal selection.

This study assembles the chromosome-level genome of Saccharomyces bayanus and compares it to its parental species to understand genome divergence after hybridization.

The paper introduces PhyloVelo, a method that uses monotonically expressed genes to reconstruct cell fate transitions, outperforming existing approaches in embryo development and tumor evolution analysis.

The paper identifies a mitochondrial DNA bottleneck during lymphocyte development, leading to homoplastic mutations despite lower mutational burden.

The paper identifies the origin of the scanning model of transcription initiation in yeasts and shows that an adenine-rich region upstream of TSSs facilitates TSS selection.

This study maps transcription start sites in yeast under nine conditions, revealing pervasive and dynamic transcription initiation with core promoters that shift in response to environmental changes.

The paper introduces YeasTSS, a database providing quantitative TSS maps and core promoters for twelve yeast species, along with integrated functional genomic data for transcription initiation studies.