Allosteric effects of the coupling cation in melibiose transporter MelB
Parameswaran Hariharan, Yuqi Shi, Bakhtiiari Amirhossein, Ruibin Liang, Rosa Viner, Lan Guan
This study investigates the allosteric effects of the coupling cation in the melibiose transporter MelB by integrating structural, HDX-MS, and simulation data to reveal how cation binding enhances sugar-binding affinity through conformational restraint.
eLife · Jan 28, 2026Peer-reviewedBiophysics