Parameswaran Hariharan

This study investigates the allosteric effects of the coupling cation in the melibiose transporter MelB by integrating structural, HDX-MS, and simulation data to reveal how cation binding enhances sugar-binding affinity through conformational restraint.

This study identifies the distinct roles of key residues in the cation-binding pocket of MelBSt through structural analysis, free energy simulations, and biochemical experiments.

This study determines the structure and dynamics of a Na+-coupled sugar transporter, revealing how mobile barriers regulate substrate binding and release.