NeurosciencebioRxivPreprint
Hyperglycemia-responsive circRNA drives diabetic neuropathic pain by competing for PUM2 binding and promoting proNT3/CCL2 in DRG neurons
Xu Li, Congcong Huang, Gokulapriya Govindarajalu…·Yuan-Xiang TAO
This study identifies cRps6kb1 as a hyperglycemia-responsive circRNA that drives diabetic neuropathic pain by competing with PUM2 for Nt3 3-UTR binding, increasing proNT3/CCL2 expression and nociceptive hypersensitivity.