A Divergent Class of Arylamine N-Acetyltransferases Catalyzes Convergent Amidative Condensation of Polyketides in Manumycins Biosynthesis
Yan Gao, Baodi Ma, Qiaqia Zhou, Minghe Luo, Guangzheng Wei, Zhi Xiu Lin, Zixin Deng, Xudong Kong, Xudong Qu
The paper identifies a novel class of arylamine N-acetyltransferases that catalyze amidative condensation of polyketides, enabling new strategies for combinatorial biosynthesis of polyketide amides and manumycin derivatives.
bioRxiv · Apr 16, 2026 · PreprintSynthetic Biology