An intestinal Sir2-HSF1-ATGL1 pathway regulates lipolysis in C. elegans
Milán Somogyvári, Saba Khatatneh, Gábor Hajdú, Bar Sotil, József Murányi, Csaba Sőti
The paper identifies an intestinal pathway in C. elegans where SIR-2.1 and HSF-1 regulate lipolysis through ATGL-1, showing context-specific interactions and implications for stress resilience and aging.
bioRxiv · Apr 11, 2024 · PreprintMolecular Biology