RNA G-quadruplexes mark repressive upstream open reading frames in human mRNAs
Pierre Murat, Giovanni Marsico, Barbara Herdy, Avazeh Tashakkori Ghanbarian, Guillem Portella, Shankar Balasubramanian
The paper identifies RNA G-quadruplexes in 5-UTRs as repressive elements that hinder translation by promoting upstream open reading frames, and shows helicases interact with these structures to regulate translation.
bioRxiv · Nov 22, 2017 · PreprintGenomics