Pierre Murat

This study maps DNA supercoiling and chromatin interactions during human stem cell differentiation, showing that gene activation increases negative supercoiling and correlates with enhanced DNA contacts.

This paper develops a pooled paired prime editing screen to generate large-scale deletions across the genome, identifying non-coding regions with fitness effects and demonstrating the feasibility of genome-wide deletion perturbation.

This paper develops a CRISPR-based method to generate large-scale structural genomic rearrangements in human cells, revealing selection pressures and gene expression impacts of these changes.

The paper uses enhancer scrambling to study a super-enhancer of the OTX2 gene, finding that a single DNase I hypersensitive site predominantly controls its expression.

This study shows that DNA replication initiation sites drive mutagenesis and genomic rearrangements in cancers by affecting repair processes and mutational patterns.

The paper maps human DNA replication origins and their efficiency, showing hierarchical organization within initiation zones.

This study shows that replication origins in humans increase mutation rates and influence gene expression and mRNA isoform usage through mutagenic processes during DNA replication.

The paper identifies a G quadruplex binding domain in Timeless and shows its collaboration with DDX11 to process G4 structures during DNA replication.

This study shows that 5-formylcytosine (5fC) influences nucleosome positioning through covalent histone-DNA interactions in mouse embryonic stem cells.

The paper identifies RNA G-quadruplexes in 5-UTRs as repressive elements that hinder translation by promoting upstream open reading frames, and shows helicases interact with these structures to regulate translation.