DISC1 regulates N-Methyl-D-Aspartate receptor dynamics: Abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness
Elise L.V. Malavasi, Kyriakos D. Economides, Ellen Grünewald, Paraskevi Makedonopoulou, Philippe Emmanuel Gautier, Shaun Mackie, Laura C. Murphy, Hannah Murdoch, Darragh Crummie, Fumiaki Ogawa, Daniel L. McCartney, Shane T. O’Sullivan, Karen Burr, Helen Scott Torrance, Jonathan Phillips, , J. Kirsty Millar
This study shows that a DISC1 mutation linked to mental illness disrupts NMDAR dynamics and synaptic function in neurons, affecting excitatory synapses and vesicle dynamics.
Translational Psychiatry · Sep 6, 2018Peer-reviewedNeuroscience