David Jonathan Price

Loss of PAX6 alters the excitatory/inhibitory neuronal ratio in human cerebral organoids

This study shows that PAX6 deficiency in human cerebral organoids leads to an increased inhibitory neuron population and altered excitatory/inhibitory ratio due to dysregulated PTN-PTPRZ1 signaling.

16p11.2 locus decelerates subpallial maturation and limits variability in human iPSC-derived ventral telencephalic organoids

The paper shows that 16p11.2 microdeletions increase developmental variability and prolong the cell cycle of human subpallial progenitors by lengthening their G1 phase in organoids.

Pax6 loss alters the morphological and electrophysiological development of mouse prethalamic neurons

This study shows that Pax6 loss affects neurite extension, axon initial segment properties, and electrophysiological function in developing mouse prethalamic neurons.

PAX6 LIMITS THE COMPETENCE OF DEVELOPING CEREBRAL CORTICAL CELLS

This study shows that Pax6 limits the competence of developing cortical progenitors to respond to morphogens, preventing inappropriate lineage generation.

Developmental resilience of synaptome architecture

The paper shows that synaptome remodelling in mice with Pax6 mutation restores normal developmental trajectory, reversing neurodevelopmental disorder symptoms.

Identifying developing interneurons as a potential target for multiple genetic autism risk factors in human and rodent forebrain.

The paper identifies developing interneurons as a potential target for autism genetic risk factors by analyzing human and rodent neural data.

The role of the diencephalon in the guidance of thalamocortical axons in mice

This study investigates the role of the diencephalon in guiding thalamocortical axons in mice, finding that molecular cues in the thalamus are critical for proper topographic mapping.

Expression of genes in the 16p11.2 locus during human fetal cortical neurogenesis.

The paper identifies ALDOA and KIF22 as the only 16p11.2 transcripts enriched in human fetal cortical progenitors and hypothesizes their dosage changes may contribute to ASD in CNV patients.

Tissue-specific actions of Pax6 on proliferation-differentiation balance in the developing forebrain are Foxg1-dependent

The paper shows Pax6 has opposite effects on proliferation-differentiation balance in murine diencephalon and cortex, with Foxg1 mediating these differences.

DISC1 regulates N-Methyl-D-Aspartate receptor dynamics: Abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness

This study shows that a DISC1 mutation linked to mental illness disrupts NMDAR dynamics and synaptic function in neurons, affecting excitatory synapses and vesicle dynamics.