The core MICOS complex subunit Mic60 has been substituted by two cryptic mitofilin-containing proteins in Euglenozoa
Shaghayegh Sheikh, Barbora Knotkova, Corinna Benz, Marek Eliáš, Tomáš Bílý, Alexey Bondar, Martina Tesařová, Eva Stříbrná, Jiří Heller, Michael Meinecke, Hassan Hashimi
The paper shows that Euglenozoa replaced the Mic60 subunit of the MICOS complex with two mitofilin-containing proteins, Mic34 and Mic40, which have distinct structural and functional properties.
Molecular Biology and Evolution · Oct 29, 2025Peer-reviewedMolecular Biology