A structure-based deep learning framework for protein engineering
Raghav Shroff, Austin W. Cole, Barrett R. Morrow, Daniel J. Diaz, Isaac Donnell, Jimmy Gollihar, Andrew D. Ellington, Ross T Thyer
This paper introduces a 3D convolutional neural network for protein engineering that identifies gain-of-function mutations, validated by experimental improvements in protein stability.
bioRxiv · Nov 8, 2019 · PreprintSynthetic Biology