Human Smc5/6 recognises transcription-generated positive DNA supercoils
Aurélie Diman, Gaël Panis, Cédric Castrogiovanni, Julien Prados, Bastien Baechler, Michel Strubin
The paper shows that human Smc5/6 binds preferentially to circular extrachromosomal DNA and localizes to highly transcribed chromosomal regions, revealing its role in DNA topology management during transcription.
Nature Communications · Sep 6, 2024Peer-reviewedMolecular Biology