Julien Prados

This study creates a single-nucleus RNA-seq atlas of Astyanax mexicanus embryogenesis, revealing tissue-specific transcriptional tempo shifts and developmental microevolution mechanisms.

This study shows that post-mitotic cortical neurons retain birthdate-dependent differentiation potential, with early-born neurons maintaining a broader repertoire than late-born neurons.

This study compares prenatal cortical development in two rodents, showing that major developmental milestones occur prenatally in Acomys, challenging the view that postnatal experience is essential for early brain maturation.

Deleting TNFR1 in astrocytes improves memory in aged Alzheimer's mice by rebalancing hippocampal circuitry excitability through synaptic pathway changes.

This study identifies alcohol dehydrogenases as critical for Streptococcus pneumoniae fitness during influenza-driven superinfection, revealing a metabolic dependency that can be targeted therapeutically.

This study shows neurogliaform cells mediate interhemispheric inhibition and modulate sensory perception by affecting pyramidal neuron activity in the mouse barrel cortex.

This paper compares antiviral and antibacterial responses in murine and human precision cut lung slices (PCLS) using transcriptomics, showing distinct immune profiles due to differences in tissue resident immune cell composition.

The paper shows that human Smc5/6 binds preferentially to circular extrachromosomal DNA and localizes to highly transcribed chromosomal regions, revealing its role in DNA topology management during transcription.

This study identifies SNP-dependent mechanisms in inbred mice that confer resistance to transgenerational endocrine disruption caused by DEHP exposure.

The paper traces transcriptional trajectories of progenitors and neurons during mouse neocortex development, showing how molecular states from progenitors shape neuronal diversity.

The paper develops ConnectID, a method linking connectome and transcriptome in single neurons, identifying transcriptional modules associated with axonal projections to specific cortical and subcortical targets.