Molecular BiologyNature CommunicationsPeer-reviewed
Human Smc5/6 recognises transcription-generated positive DNA supercoils
Aurélie Diman, Gaël Panis, Cédric Castrogiovanni…·Michel Strubin
The paper shows that human Smc5/6 binds preferentially to circular extrachromosomal DNA and localizes to highly transcribed chromosomal regions, revealing its role in DNA topology management during transcription.
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