Fibroblast activation protein enzyme deficiency prevents liver steatosis, insulin resistance and glucose intolerance and increases fibroblast growth factor-21 in diet induced obese mice
Sumaiya Chowdhury, Sunmi Song, Hui Emma Zhang, Xin Maggie Wang, Margaret G. Gall, Denise Ming Tse Yu, Angelina J. Lay, Michelle Sui Wen Xiang, Kathryn A. Evans, Stefanie Wetzel, Yolanda Liu, Belinda Yau, Andrew L. Coppage, Lisa Lo, Rebecca A. Stokes, , Mark D. Gorrell
This study shows that FAP deficiency in diet-induced obese mice reduces liver steatosis, insulin resistance, and glucose intolerance while increasing FGF-21 levels.
bioRxiv · Nov 4, 2018 · PreprintPathology