Developmental chromatin restriction of pro-growth gene networks acts as an epigenetic barrier to axon regeneration in cortical neurons
Ishwariya Venkatesh, Vatsal Mehra, Zimei Wang, Ben L. Callif, Murray G. Blackmore
The paper develops a bioinformatic pipeline to analyze chromatin accessibility and gene networks in cortical neurons, finding that developmental chromatin restriction limits axon regeneration and identifies potential pioneer factors to overcome this barrier.
Developmental Neurobiology · May 22, 2018Peer-reviewedNeuroscience