Ishwariya Venkatesh

KiMA provides an open-source tool for analyzing rodent gait and kinematics, integrating pose estimation with automated parameter calculation and visualization.

This study identifies RARA and RARG as cooperative regulators of axon regeneration in the CNS and PNS by reactivating developmental growth programs through combinatorial transcriptional control.

This study shows that three-dimensional genome organization in adult neurons encodes regenerative potential, with injury partially reversing this structure to re-engage developmental gene programs.

The paper shows PATZ1 promotes chromatin accessibility in injured neurons by remodeling nucleosomes at enhancers, facilitating axon regeneration.

This paper identifies a small molecule DM04 that mimics retinoic acid's effects on axon growth and motor recovery after spinal cord injury, acting through a non-canonical mechanism.

DeNAT is a deep-learning tool that automatically measures neurite outgrowth in injury models with high accuracy and reduced variability compared to manual methods.

This study identifies NR2F1 and NR2F6 as nuclear receptor transcription factors that promote axon regeneration in the corticospinal tract through chromatin remodeling, enhancer redeployment, and translational reprogramming.

This study maps chromatin accessibility changes in mouse forebrain development and shows that PATZ1 can reverse epigenetic restrictions in adult neurons to enhance axon regeneration after injury.

This study profiles the transcriptional response of supraspinal cell types to spinal injury in mice, finding that CST neurons respond more strongly to injuries closer to the brain than to distant spinal injuries.

The paper identifies novel transcription factor synergies that enhance axon growth by analyzing co-occupancy patterns and validating them through experimental screens and animal models.

This study shows KLF6 promotes axon growth in CNS neurons by co-occupying regulatory DNA with STAT3, leading to synergistic gene expression changes.

The paper develops a bioinformatic pipeline to analyze chromatin accessibility and gene networks in cortical neurons, finding that developmental chromatin restriction limits axon regeneration and identifies potential pioneer factors to overcome this barrier.