Capturing α-synuclein polymorphism with AlphaFold 3 and rivals
Richard P. Price, Ben LaCourse, Aderik Voorspoels, Luc G. Elliott, Alana Maerivoet, Adam J. Simpkin, Shahram Mesdaghi, Alexandra Stafford-Dodsworth, Jillian Madine, Daniel John Rigden
This paper evaluates AlphaFold 3 and other methods in predicting α-synuclein polymorphs using a reference set of known structures and finds they can generate fibril-like models, though performance varies with template use.
bioRxiv · Dec 9, 2025 · PreprintBioinformatics