Jillian Madine

Medin-Induced Pro-inflammatory and Prothrombotic Activation of Coronary Artery Endothelial Cells: A Potential Novel Mediator Linking Aging and Atherosclerosis

This study shows medin induces pro-inflammatory and prothrombotic changes in endothelial cells and is strongly associated with coronary plaque burden and inflammation.

Capturing α-synuclein polymorphism with AlphaFold 3 and rivals

This paper evaluates AlphaFold 3 and other methods in predicting α-synuclein polymorphs using a reference set of known structures and finds they can generate fibril-like models, though performance varies with template use.

Atomic structures of medin and Aβ fibrils reveal polymorphic remodeling in mixed amyloid systems

This study determines the cryo-EM structures of Aβ40 and medin fibrils in vitro, revealing polymorphic remodeling and mixed amyloid interactions.

Medin Induces Pro-Inflammatory Activation of Human Brain Vascular Smooth Muscle Cells

This study shows that Medin induces pro-inflammatory activation in human brain vascular smooth muscle cells via NF-kappaB, without affecting structural proteins involved in phenotypic transformation.

Investigating Medin Cleavage Accessibility in MfgE8: Conformational Insights Derived from Molecular Dynamics Simulations and AlphaFold2 Models

This study uses molecular dynamics simulations and AlphaFold2 models to investigate MfgE8 conformations and how they affect medin cleavage site accessibility.