Multiscale causal network models of Alzheimer’s disease identify VGF as a key regulator of disease
Noam D. Beckmann, Wei‐Jye Lin, Minghui Wang, Ariella T. Cohain, Pei Wang, Weiping Ma, Ying‐Chih Wang, Cheng Shi Jiang, Mickaël Audrain, Phillip Comella, Siddharth P. Hariharan, Gillian M. Belbin, Allan I. Levey, Nicholas T. Seyfried, Eric B. Dammer, , Eric E. Schadt
The paper identifies VGF as a key regulator of Alzheimer’s disease using multiscale causal network models and validates its protective role in mouse models.
bioRxiv · Nov 4, 2018 · PreprintGenomics