Nicholas T. Seyfried

This study uses proteomics to identify aging and Aβ-related molecular changes in mouse brains and finds they are conserved in human AD proteomes.

This study shows ABCA7 deficiency in microglia disrupts lysosomal and lipid homeostasis, impairs phagocytosis, and negatively affects neuronal health in Alzheimer's disease.

This study uses human spinal cord organoids to model C9orf72 ALS, identifying early RNA splicing dysregulation and RBP network dysfunction as key features of the disease.

This study integrates multi-omics data from DLPFC with GWAS summary data to identify PD risk genes, finding significant overlaps between bulk and cell-type-aware TWAS and PWAS results.

This study identifies TDP-43 dysfunction as a cause of cryptic circular RNA formation in ALS/FTD, showing their association with disease-relevant protein loss and potential as biomarkers.

This study shows that Syndecan-4 has both HS-dependent and HS-independent effects on Aβ amyloid homeostasis, reducing amyloid deposition in a mouse model.

This study examines the molecular effects of aducanumab treatment in 5XFAD mice, revealing sex-dependent and IgG-mediated changes in amyloid and associated pathways.

This study shows that PSEN1 mutant marmoset fibroblasts exhibit multi-omic signatures similar to Alzheimer's disease in humans, highlighting sex-specific differences and disease-relevant pathways.

This study identifies proteins and networks associated with behavioral and psychological symptoms of dementia using proteomic data from multiple cohorts.

This paper introduces SPARO, a method to simultaneously profile transcriptomes and proteomes of neural cell types, revealing mRNA-protein discordance patterns in astrocytes and neurons.

The paper identifies TMEM106B fibril accumulation as a shared mechanism in neurodegeneration linked to genetic variants in TMEM106B and GRN.

This study identifies synaptic proteome changes in response to neuroinflammation, revealing mitochondrial and MAPK signaling disruptions in excitatory neurons linked to Alzheimer's disease.

The paper investigates how neurodevelopmental disorder-associated variants affect mitochondrial proteins and finds convergent effects on mitochondrial translation in two high-risk CNVs.

The paper identifies five therapeutic targets for Alzheimer's disease by integrating phenotypic and proteomic screening in murine microglial cells.

This study creates a multi-omic atlas of the choroid plexus in Alzheimer's disease, identifying disease-associated cell state transitions and functional impairments.

The paper identifies RNA-binding proteins interacting with tau's repeat domain using proximity labeling, showing their enrichment in Alzheimer's and tauopathies.

The paper identifies six CSF proteomic subtypes in Alzheimer's disease, linking BBB dysfunction to reduced tau and synaptic biomarkers, particularly in African Americans and men.

The paper identifies novel Kv1.3 channel-interacting proteins in T-cells using proximity labeling, revealing interactions with immune signaling and trafficking machinery, and links some interactors to autoimmunity risk.

This study shows that INPP5D/SHIP1 regulates endo-lysosomal function and cargo-selective phagocytosis in human microglia, linking its dysfunction to Alzheimer's disease pathology.

This study identifies BAG3's role in astrocytic proteostasis in Alzheimer's disease by showing its interactions with autophagy, proteasome, and retromer components, and its impact on Aβ clearance.

The paper defines cognitive resilience as differential cognitive decline rates after adjusting for neuropathologies, develops a framework to quantify it using molecular signatures from post-mortem brain data, and translates these findings to living individuals.

This study identifies a PERK-B/DLX1 pathway as a novel driver of tau pathology in human PSP and flies, showing DLX1 promotes tau toxicity.

The paper compares two rat synucleinopathy models using multi-omics data to identify disease mechanisms and drug targets relevant to Parkinson's disease.

This study develops an orthogonal ubiquitin transfer cascade to profile Parkin substrates, revealing roles in DNA replication, protein transport, and mitophagy.

This study uses multiplex proteomics to identify CSF biomarkers of clinical and neuropathological heterogeneity in Lewy body dementia.

This study identifies molecular subtypes based on cryptic exon burden in hippocampal tissue, revealing proteomic changes linked to TDP-43 pathology in LATE and Alzheimer's disease.

The paper uses an omnibus xWAS pipeline to integrate snRNA-seq and GWAS data, identifying 91 independent cell-type-specific risk genes for Alzheimer's disease dementia.

The paper identifies three brain multi-omic molecular subtypes of neuroticism linked to Alzheimer's disease traits, with subtype N1 showing the strongest associations.

The paper identifies proteomic differences in cerebrospinal fluid between sporadic and familial ALS subtypes using network analysis and validates biomarkers across neurodegenerative diseases.