Noam D. Beckmann

DNT: Diploid Genomic Foundation Model

The paper introduces a diploid genomic foundation model to represent diploid genotypes in genomic language models, improving variant discrimination in compound-heterozygous cases.

Genetic Associations with Temporal Modeling of Alzheimer's Disease Progression Supports a Novel Paradigm for Disease Risk

This paper uses temporal modeling of Alzheimer's disease progression with metabolomics data to identify novel genetic loci associated with disease speed, independent of traditional case-control associations.

A study of gene expression in the living human brain

This study compares gene expression in living and postmortem human brain tissue, finding significant differences that challenge the assumption that postmortem data accurately represents living brain gene expression.

Dual-specificity protein phosphatase 6 (DUSP6) overexpression reduces amyloid load and improves memory deficits in male 5xFAD mice

This study shows that DUSP6 overexpression in the dorsal hippocampus of male 5xFAD mice reduces amyloid load and improves memory, while also reducing neuroinflammation in both sexes.

Divergent landscapes of A-to-I editing in postmortem and living human brain

This study compares A-to-I RNA editing in postmortem and living human brain tissues, revealing significant differences in editing levels and their association with cellular processes and neurological conditions.

Characterizing cell type specific transcriptional differences between the living and postmortem human brain.

The paper compares gene expression differences between living and postmortem human brain samples using snRNA-seq and develops a model to account for these differences in analysis.

IL10RB as a key regulator of COVID-19 host susceptibility and severity

The paper identifies IL10RB as a key regulator of COVID-19 host susceptibility and severity through integrative analysis of genetic and transcriptomic data, and validates potential drug repositioning candidates.

Polygenic risk scores lack prognostic value for adults with severe mental illness

This study evaluates the prognostic value of polygenic risk scores for schizophrenia and finds they do not improve outcome prediction beyond clinical features.

Towards a Fine-scale Population Health Monitoring System

This study links genomic data with EHRs to identify health outcomes enriched in sub-populations, revealing both known and novel associations.

A Molecular network approach reveals shared cellular and molecular signatures between chronic fatigue syndrome and other fatiguing illnesses

This study identifies shared molecular signatures between chronic fatigue syndrome and other fatiguing illnesses using RNA-sequencing data from blood samples.

Single Cell-type Integrative Network Modeling IdentifiedNovel Microglial-specific Targets for the Phagosome inAlzheimer's disease

The paper develops a computational systems biology approach to identify novel microglial-specific targets for the phagosome in Alzheimer's disease using integrated transcriptome and genotype data.

Molecular Networks and Key Regulators of the Dysregulated Neuronal System in Alzheimer’s Disease

This study identifies molecular networks and key regulators in Alzheimer’s Disease using integrative genomics and experimental validation.

Multiscale causal network models of Alzheimer’s disease identify VGF as a key regulator of disease

The paper identifies VGF as a key regulator of Alzheimer’s disease using multiscale causal network models and validates its protective role in mouse models.