Bin Zhang

Cell vulnerability within the sublaterodorsal tegmental nucleus underlies REM sleep behaviour disorder in prodromal α-synucleinopathy

The paper shows that synucleinopathy in SLD glutamatergic neurons causes RBD and Parkinson's-like deficits in mice.

DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity

This study shows that DAP12 deficiency reduces tau-induced inflammation and myelin loss in mice, despite increased tau pathology, by altering microglia-oligodendrocyte interactions.

Cell signaling pathways discovery from multi-modal data

The paper introduces Incytr, a method for discovering cell signaling pathways from multi-omics data, demonstrating its application in disease contexts and showing its utility for drug discovery and understanding cell communication.

Hyperexcitability precedes CA3 hippocampal neurodegeneration in a dox-regulatable TDP-43 mouse model of ALS-FTD.

This study shows that hyperexcitability precedes neurodegeneration in a TDP-43 mouse model of ALS-FTD, but targeting hyperexcitability does not prevent neuron loss.

Bridging the Gap: Multi-Omics Profiling of Brain Tissue in Alzheimer's Disease and Older Controls in Multi-Ethnic Populations

This paper presents a multi-omics dataset from multi-ethnic Alzheimer's disease brain donors, including transcriptome, genome, and proteome data, to improve precision medicine for underrepresented populations.

Dual-specificity protein phosphatase 6 (DUSP6) overexpression reduces amyloid load and improves memory deficits in male 5xFAD mice

This study shows that DUSP6 overexpression in the dorsal hippocampus of male 5xFAD mice reduces amyloid load and improves memory, while also reducing neuroinflammation in both sexes.

Divergent landscapes of A-to-I editing in postmortem and living human brain

This study compares A-to-I RNA editing in postmortem and living human brain tissues, revealing significant differences in editing levels and their association with cellular processes and neurological conditions.

LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology spread

This study shows that LRRK2 kinase inhibition reverses tau pathology progression in mice with the G2019S mutation but not in wildtype mice.

Human brain aging heterogeneity observed from multi-region omics data reveals a subtype closely related to Alzheimer's disease

The paper identifies an AD-like subtype in brain aging across multiple regions, showing overlap with AD gene signatures and regional differences in gene expression.

Integrated transcriptomic analysis of human induced pluripotent stem cell-derived osteogenic differentiation reveals a regulatory role of KLF16

The paper identifies KLF16 as an inhibitory regulator of osteogenic differentiation through transcriptomic analysis of human iPSC-derived cells and in vivo validation.

Proteomic profiling of intracranial atherosclerotic plaque in the human brain

This study uses proteomic profiling of intracranial atherosclerotic plaques to identify differentially expressed proteins associated with ICAD, revealing potential biomarkers and biological pathways involved in the disease.

Proteomic signaling of dual specificity phosphatase 4 (DUSP4) in Alzheimer's disease

This study investigates the proteomic and phosphoproteomic effects of DUSP4 overexpression in 5xFAD mice, revealing sex-specific molecular mechanisms and validating findings in human AD cohorts.

Shared and divergent transcriptomic regulation in nucleus accumbens D1 and D2 medium spiny neurons by cocaine and morphine

The paper examines transcriptomic changes in D1 and D2 medium spiny neurons of the nucleus accumbens after cocaine and morphine exposure, revealing shared and divergent regulatory patterns.

Convergent coexpression of autism associated genes suggests some novel risk genes may not be detectable in large-scale genetic studies

The paper identifies novel autism risk genes by analyzing convergent coexpression patterns in brain samples, showing these genes may not be detected by sequencing studies.

INPP5D limits plaque formation and glial reactivity in the APP/PS1 mouse model of Alzheimer's disease

The paper shows that INPP5D reduces plaque formation and glial reactivity in Alzheimer's disease mouse models through microglial knockdown and spatial transcriptomics analysis.

Expansion of RNA sequence diversity and RNA editing rates throughout human cortical development

The paper examines RNA editing changes during human cortical development, identifying expansion of editing sites and their genetic regulation linked to neurological disorders.

Sex disparities in influenza: a multiscale network analysis

This study uses a network-based approach to analyze sex differences in immune responses to influenza virus infection in ferrets, identifying sex-biased gene expression and pathways.

Single-cell Transcriptomic Atlas of the Human Substantia Nigra in Parkinson's Disease

This study generates a large single-cell RNA sequencing dataset of the human substantia nigra in Parkinson's disease, identifies DA neuron subtypes, and reveals molecular changes associated with PD.

Large-Scale Deep Multi-Layer Analysis of Alzheimer's Disease Brain Reveals Strong Proteomic Disease-Related Changes Not Observed at the RNA Level

The paper analyzes proteomic data from Alzheimer's disease brains, revealing disease-related changes not seen at the RNA level and identifying potential therapeutic targets.

Transcriptomic changes highly similar to Alzheimer's disease are observed in a subpopulation of individuals during normal brain aging

The paper identifies transcriptomic changes in normal aging brains that resemble Alzheimer's disease in specific subgroups, suggesting early molecular links between aging and LOAD.

The mouse cortico-basal ganglia-thalamic network

The paper maps functional domains and subnetworks in the cortico-basal ganglia-thalamic loop in mice, revealing complex patterns of convergence and divergence.

Tissue Specific Age Dependence of the Cell Receptors Involved in the SARS-CoV-2 Infection

This study analyzes the tissue-specific age dependence of cell receptors involved in SARS-CoV-2 infection and identifies key regulators and host processes hijacked by the virus.

Tau pathology spreads between anatomically-connected regions of the brain and is modulated by a LRRK2 mutation

This study shows tau pathology spreads along anatomical brain connections and a LRRK2 mutation alters its directionality in mice.

Single-cell atlas of progressive supranuclear palsy reveals a distinct hybrid glial cell population

The paper analyzes single-cell transcriptomic data from PSP brains to identify hybrid glial cell populations and their role in disease progression.

Single-cell analysis identifies a key role for Hhip in murine coronal suture development

The paper uses single-cell RNA-seq to identify Hhip's role in murine coronal suture development, showing its necessity for maintaining suture mesenchyme and osteogenic fronts.

A joint analysis of longevity and age-related disease variants for gene expression association

This study analyzes genetic variants associated with longevity and age-related diseases to understand their impact on gene expression.

Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent TYROBP-APOE link in wild-type and Alzheimer's-related mice

This study shows that TYROBP-APOE signaling in microglia can occur without TREM2 and influences AD pathology in mouse models.

AD-linked R47H-TREM2 mutation induces disease-enhancing proinflammatory microglial states in mice and humans

This study identifies R47H-TREM2 mutation-induced proinflammatory microglial states in human AD and tauopathy mice, showing Akt pathway involvement and potential therapeutic targets.

Snca-GFP knock-in mice reflect patterns of endogenous expression and pathological seeding

This paper develops a mouse model expressing aSyn-GFP under native regulatory elements, showing it mirrors endogenous aSyn expression and pathology.

A Consensus Proteomic Analysis of Alzheimer's Disease Brain and Cerebrospinal Fluid Reveals Early Changes in Energy Metabolism Associated with Microglia and Astrocyte Activation

The paper identifies protein network modules in Alzheimer's disease brains and cerebrospinal fluid that are associated with energy metabolism and neuroinflammation, suggesting potential biomarkers and therapeutic targets.