The Red Blood Cell Surface Defines a Distinct Tumor DNA Compartment for Liquid Biopsy
Elias Elias, H Ruger, Jarrod D. Predina, Benjamin A. Bleiberg, Phurin Areesawangkit, Estela Noguera-Ortega, Abhishek Kulkarni, Jeffrey C. Thompson, Michael G. S. Shashaty, Corey Jay Langer, Steven M. Albelda, Nilam S. Mangalmurti
This study identifies RBC-bound tumor DNA as a distinct compartment for liquid biopsy, showing it is more abundant and concordant with tumor tissue than plasma DNA.
bioRxiv · Oct 10, 2026 · PreprintCancer Biology