Polygenic Risk Score of Sporadic Late Onset Alzheimer Disease Reveals a Shared Architecture with the Familial and Early Onset Forms
Carlos Cruchaga, Jorge L. Del‐Aguila, Benjamin A. Saef, Kathleen Black, María Victoria Fernández, John Budde, Laura Ibáñez, Yuetiva K. Deming, Manav Kapoor, Giuseppe Tosto, Richard P Mayeux, David M. Holtzman, Anne M. Fagan, John C. Morris, Randall John Bateman, , Oscar Harari
The paper constructs polygenic risk scores for sporadic late-onset Alzheimer's Disease and finds shared genetic architecture with familial and early-onset forms, showing varying odds ratios across cohorts.
Alzheimer s & Dementia · Sep 21, 2017Peer-reviewedGenetics