Oscar Harari

This paper presents an end-to-end framework for single-cell whole-transcriptome spatial profiling of post-mortem human brain tissue, improving library quality and enabling cross-sample harmonization.

The paper identifies NINL as a modulator of tau aggregation through integrative genomic and functional analyses linking it to proteostasis dysfunction in FTD and AD.

The paper investigates cell-to-cell communication in Alzheimer's disease to characterize disease biology and suggest new avenues for therapeutic intervention.

iSODA is a web-based tool for analyzing single- and multi-omics data, offering visualization, normalization, and integration methods like MOFA and SNF.

This study identifies cell-type-specific and shared gene regulatory networks modulating APOE expression in microglia and astrocytes using single-cell RNA sequencing data from AD patients.

The paper identifies novel TREM2 interactors at the ER-mitochondria interface in human microglia using TurboID proximity labeling, revealing a role for TREM2 in MERC structural plasticity and potential involvement in Alzheimer's disease.

The paper integrates multi-omics data from Alzheimer's disease cohorts to identify molecular profiles linked to disease progression and severity.

This study identifies estrogen's role in suppressing neuro-inflammation and links its loss to increased Alzheimer's disease risk in women through systems pharmacology and signaling network analysis.

This study identifies increased circPSEN1 levels in ADAD brains compared to sporadic AD and controls, suggesting a potential role in neuroinflammatory processes.

This paper identifies seven genome-wide significant loci associated with early neurological instability after acute ischemic stroke, linking excitotoxic genes to poor outcomes.

This study identifies metabolomic and lipidomic signatures in Alzheimer's disease brains with different genetic risk factors and finds associations with disease subtypes and progression.

The paper uses GWAS, PRS, and MR to show a genetic link between Parkinson's disease and CSF Aβ42 and APOE locus.

The paper integrates genomic and proteomic data across multiple tissues to identify protein quantitative loci (pQTL) and their implications for neurodegenerative diseases.

This study identifies a significant genetic correlation between Parkinson disease and melanoma, highlighting shared genes and pathways.

This study identifies genetic variants in the MS4A gene cluster associated with higher sTREM2 levels and reduced Alzheimer disease risk, suggesting MS4A4A regulates sTREM2 and contributes to AD pathogenesis.

This study uses single-nuclei RNA-seq to compare cell proportions and gene expression in Mendelian and sporadic AD brains, identifying reduced excitatory neurons in a Mendelian carrier and proposing best practices for analysis.

The paper identifies a genetic variant in TMEM106B associated with increased neuronal proportion in neurodegenerative and cognitive normal cohorts, suggesting a role in neuronal protection.

The paper identifies 129 differentially expressed genes in the PFC of alcoholics and links them to pathways and modules associated with alcohol dependence and consumption.

This study identifies how genetic risk variants for Alzheimer's disease affect cerebral cortex cell-type proportions in bulk RNA-seq data using digital deconvolution.

This study evaluates gene-based methods for family-based analyses of familial late-onset Alzheimer disease, identifying novel candidate genes.

The paper constructs polygenic risk scores for sporadic late-onset Alzheimer's Disease and finds shared genetic architecture with familial and early-onset forms, showing varying odds ratios across cohorts.

This study identifies a haplotype lowering PU.1 expression in myeloid cells that delays Alzheimer’s disease onset by affecting gene expression and function.