Cardiac defects in spinal muscular atrophy and the role of SMN in cardiomyocyte homeostasis
Reid Garner, Leillani L. Ha, Flávia C. Nery, Rebecca G. Spellman, Lucia Chehadé, Benjamin Glennon, Eric J. Eichelberger, Salomé Da Silva Duarte Lepez, Alec J. Johnstone, Rashmi Kothary, Kathryn J. Swoboda, Christiano R. R. Alves
This study examines cardiac pathology in spinal muscular atrophy (SMA) and shows that SMN deficiency causes metabolic and PTEN signaling changes in cardiomyocytes.
bioRxiv · Aug 9, 2026 · PreprintPathology