Author

Rebecca G. Spellman

Massachusetts General HospitalORCID 0000-0002-4615-2013Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Genetic & Genomic Medicine· 1 Pathology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Christiano R. R. AlvesiD· 2 shared Kathryn J. SwobodaiD· 2 shared Leillani L. HaiD· 2 shared Salomé Da Silva Duarte LepeziD· 2 shared Alec J. Johnstone· 1 shared Benjamin Glennon· 1 shared Elizabeth A. Arruda· 1 shared Emma RodriguesiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersPathology

Christiano R. R. AlvesORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Cardiac defects in spinal muscular atrophy and the role of SMN in cardiomyocyte homeostasis

Reid Garner, Leillani L. Ha, Flávia C. Nery, Rebecca G. Spellman, Lucia Chehadé, Benjamin Glennon, Eric J. Eichelberger, Salomé Da Silva Duarte Lepez, Alec J. Johnstone, Rashmi Kothary, Kathryn J. Swoboda, Christiano R. R. Alves

This study examines cardiac pathology in spinal muscular atrophy (SMA) and shows that SMN deficiency causes metabolic and PTEN signaling changes in cardiomyocytes.

bioRxiv · Aug 9, 2026 · PreprintPathology

Early Life Safety Profiling of Gene Therapy for Spinal Muscular Atrophy: A Case Series Analysis

Rebecca G. Spellman, Leillani L. Ha, Salomé Da Silva Duarte Lepez, Elizabeth A. Arruda, Emma Rodrigues, Kathryn J. Swoboda, Christiano R. R. Alves

This study evaluates the safety of onasemnogene abeparvovec gene therapy in SMA patients, showing transient liver enzyme elevations that normalized, with no impact from concurrent nusinersen treatment.

Gene Therapy · Apr 1, 2025Peer-reviewedGenetic & Genomic Medicine