Interphotoreceptor matrix proteoglycans IMPG1 and IMPG2 proteolyze in the SEA domain and reveal localization mutual dependency
Benjamin Mitchell, Chloe Coulter, Werner J. Geldenhuys, Scott B. Rhodes, Ezequiel M. Salido
This study shows that proteolysis of IMPG1 and IMPG2 in the SEA domain is part of their maturation and that their trafficking is co-dependent, with implications for vision diseases.
Scientific Reports · Sep 15, 2022Peer-reviewedMolecular Biology