Multiple Sclerosis Drug Fingolimod Exhibits Antibacterial Activity through Bacterial Membrane Permeabilization
Antara Syam, Benjamin Rees, Sebastián Cardona Cuervo, Fengtian Xue, Alexander J. Sodt, Ekaterina M. Nestorovich, Tatiana K. Rostovtseva, Sergey M. Bezrukov, John S. Choy
This study reveals that fingolimod, a multiple sclerosis drug, disrupts bacterial membranes through permeabilization, providing insight into its off-target antimicrobial activity.
bioRxiv · Mar 2, 2026 · PreprintMicrobiology