The Role of SARS-CoV-2 Nucleocapsid Protein Persistence in Inducing Chronic Type I Interferon and Mitochondrial Dysfunction.
Andreas Koenig, Mohammad Quasem, Benjamin Zink, Doniyorbek Abdulla-Zoda, Priyanka Karunanidhi, Karolina Sienko, Christian Geier, Venkatesh Jayaraman, Rabia N. Malik, Kanza Ahmed, Paul F. Shanley, Iwona A. Koenig
The study shows that SARS-CoV-2 nucleocapsid protein persistence without viral replication leads to type I interferon production and mitochondrial dysfunction, promoting autoimmunity.
bioRxiv · Jun 2, 2025 · PreprintImmunology