Thioredoxin interacting protein (TXNIP), a redox regulator, mediates the RAPGEF3/4 signaling dependency in primary melanoma
Sireesh Kumar Teertam, Mithalesh Kumar Singh, Sarah Altameemi, Sonia Gude, Sushmita Roy, Ryan Rossman, Michael A. Newton, Bennett Dd, Nihal Ahmad, Xiaodong Cheng, Vijayasaradhi Setaluri
This study identifies TXNIP as a downstream effector of EPAC signaling in primary melanoma, showing its role in redox regulation and melanoma progression through mTORC1 and HIF-1 pathways.
Oncogene · Jul 25, 2026Peer-reviewedCancer Biology