Cancer BiologyOncogenePeer-reviewed
Thioredoxin interacting protein (TXNIP), a redox regulator, mediates the RAPGEF3/4 signaling dependency in primary melanoma
Sireesh Kumar Teertam, Mithalesh Kumar Singh, Sarah Altameemi…·Vijayasaradhi Setaluri
This study identifies TXNIP as a downstream effector of EPAC signaling in primary melanoma, showing its role in redox regulation and melanoma progression through mTORC1 and HIF-1 pathways.
DOI 10.1038/s41388-026-03895-6