Author

Mithalesh Kumar Singh

Harold C. Simmons Comprehensive Cancer CenterORCID 0000-0002-1812-9860Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Anthony M. CruziD· 1 shared Bennett Dd· 1 shared Christina L. DecaturiD· 1 shared J. William HarbouriD· 1 shared James Jarad DollariD· 1 shared Jeffim N. KuznetsoffiD· 1 shared Mahsa SorouriiD· 1 shared Michael A. NewtoniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Anthony M. CruzORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 28, 2026

BAP1 loss and PRAME expression converge to remodel the tumor-immune ecosystem during uveal melanoma progression

James Jarad Dollar, Xiao Liu, Mithalesh Kumar Singh…·J. William Harbour

The paper profiles single-cell data from uveal melanoma to show BAP1 loss and PRAME expression drive convergent immunoregulatory changes and immune resistance.

DOI 10.64898/2026.09.23.752454

humanscRNA-seq

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Cancer BiologyOncogenePeer-reviewedJul 25, 2026

Thioredoxin interacting protein (TXNIP), a redox regulator, mediates the RAPGEF3/4 signaling dependency in primary melanoma

Sireesh Kumar Teertam, Mithalesh Kumar Singh, Sarah Altameemi…·Vijayasaradhi Setaluri

This study identifies TXNIP as a downstream effector of EPAC signaling in primary melanoma, showing its role in redox regulation and melanoma progression through mTORC1 and HIF-1 pathways.

DOI 10.1038/s41388-026-03895-6

mousebulk RNA-seq

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