Plasma derived cell-free mitochondrial DNA originates mainly from circulating cell-free mitochondria
Benoit Roch, Ekaterina Pisareva, Cynthia Sanchez, Brice Pastor, Rita Tanos, Alexia Mirandola, Thibault Mazard, Zahra Al Amir Dache, Alain Roger Thierry
The paper investigates the origin of circulating mitochondrial DNA (cir-mtDNA) and finds it primarily comes from extracellular mitochondria and vesicles, with a significant reduction when platelet activation is avoided.
bioRxiv · Sep 3, 2021 · PreprintGenomics