Alain Roger Thierry

Circulating DNA reveals nucleosome occupancy patterns that are associated with nucleosome-DNA affinity and are affected in cancer

This study uses circulating DNA to reveal nucleosome occupancy patterns linked to DNA affinity and shows their utility in cancer detection with high specificity and sensitivity.

Extracellular DNASE1L3 dysfunction fuels obesity-driven inflammation and metabolic syndrome

This study shows that reduced DNASE1L3 activity in obesity leads to increased cfDNA and inflammation, contributing to metabolic syndrome and MASLD, and that restoring DNASE1L3 can mitigate these effects.

Single- and double-strand circulating DNA fragmentomics for enhanced cancer detection performance

This paper develops a method using circulating DNA fragment end motifs and machine learning to detect cancer with high accuracy across multiple cancer types.

Neutrophil extracellular traps have auto-catabolic activity and produce mononucleosome-associated circulating DNA

This paper demonstrates that neutrophil extracellular traps (NETs) are a major source of mono-N cirDNA independent of apoptosis, and shows that NE and MPO contribute to NET autocatabolism and cirDNA release.

Plasma derived cell-free mitochondrial DNA originates mainly from circulating cell-free mitochondria

The paper investigates the origin of circulating mitochondrial DNA (cir-mtDNA) and finds it primarily comes from extracellular mitochondria and vesicles, with a significant reduction when platelet activation is avoided.