Author

Thibault Mazard

InsermORCID 0000-0002-5644-9603Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1

Frequent Co-Authors

Alain Roger ThierryiD· 3 shared Ekaterina PisarevaiD· 3 shared Alexia MirandolaiD· 2 shared Brice PastoriD· 2 shared Andrei KudriavtseviD· 1 shared Benjamin BesseiD· 1 shared Benoit Roch· 1 shared Benoît Roch· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersGenomics

Alain Roger ThierryORCID

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3 papers

Recent·Most cited

Single- and double-strand circulating DNA fragmentomics for enhanced cancer detection performance

Ekaterina Pisareva, Marianne Richaud, Séverine Tabone‐Eglinger, Thomas Bachelot, Benoît Roch, Thibault Mazard, William Jacot, Véronique Pezzella, Benjamin Besse, Fabrice André, Marc Ychou, Jacques Colinge, Alain Roger Thierry

This paper develops a method using circulating DNA fragment end motifs and machine learning to detect cancer with high accuracy across multiple cancer types.

bioRxiv · Sep 17, 2025 · PreprintGenomics

Neutrophil extracellular traps have auto-catabolic activity and produce mononucleosome-associated circulating DNA

Ekaterina Pisareva, Lucia Mihalovičová, Brice Pastor, Andrei Kudriavtsev, Alexia Mirandola, Thibault Mazard, Stéphanie Badiou, Ulrich A. Maus, Lena Ostermann, Julia Weinmann‐Menke, Elmo W. I. Neuberger, Perikles D. Simon, Alain Roger Thierry

This paper demonstrates that neutrophil extracellular traps (NETs) are a major source of mono-N cirDNA independent of apoptosis, and shows that NE and MPO contribute to NET autocatabolism and cirDNA release.

Genome Medicine · Nov 28, 2022Peer-reviewedMolecular Biology

Plasma derived cell-free mitochondrial DNA originates mainly from circulating cell-free mitochondria

Benoit Roch, Ekaterina Pisareva, Cynthia Sanchez, Brice Pastor, Rita Tanos, Alexia Mirandola, Thibault Mazard, Zahra Al Amir Dache, Alain Roger Thierry

The paper investigates the origin of circulating mitochondrial DNA (cir-mtDNA) and finds it primarily comes from extracellular mitochondria and vesicles, with a significant reduction when platelet activation is avoided.

bioRxiv · Sep 3, 2021 · PreprintGenomics