The pro-inflammatory cytokines IFN-α and TNF-α inhibit organoid-derived extravillous trophoblast invasion
Jantine van Voorden, Fangxu Lin, Souad Boussata, Remco Keijser, Liana Barenbrug, Bente Horselenberg, Ans M. M. van Pelt, Wendy Dankers, Susana M. Chuva de Sousa Lopes, Gijs Afink
This study shows that IFN-α and TNF-α reduce EVT invasion in organoid models, potentially contributing to pregnancy complications.
iScience · Jun 20, 2026Peer-reviewedDevelopmental Biology