Susana M. Chuva de Sousa Lopes

The paper compares the immediate cellular response to polyploidization across different contexts and finds conserved scaling of cell size and protein translation, with cell-cycle adaptations influencing outcomes.

This study shows that IFN-α and TNF-α reduce EVT invasion in organoid models, potentially contributing to pregnancy complications.

This study introduces Stereo-meta-seq to integrate spatial metabolomics and transcriptomics in human kidney development, revealing DHA's role in proximal tubule maturation.

This paper creates an integrated multimodal atlas of the female reproductive system across the lifespan, identifying cell types and linking them to gynaecological pathologies.

This study shows that human primordial germ cell-like cells can mature in reconstituted human fetal ovaries and amnion-like cell aggregates, with SCF being crucial for hPGCLC survival.

The paper introduces iDiscoid, a human stem cell model of post-implantation development that recapitulates key morphogenetic features and offers a platform for studying early human development.

The paper uses single-cell transcriptomics to study fetal rete testis development, identifying molecular markers and cell types in human gonads and mesonephros/epididymis.

The paper introduces SIGMA, a clusterability measure to identify meaningful subpopulations in single-cell transcriptomics data, leading to the discovery of previously overlooked phenotypes.

This paper introduces a method to efficiently generate human primordial germ cell-like cells (hPGCLCs) in 2D culture using basement membrane extract overlay and low BMP4 concentration.

The paper introduces a single-cell methylomics method to study DNA demethylation dynamics in early mammalian development and finds distinct active and passive demethylation modes in mouse and human embryos.

The paper quantifies somatic mutation accumulation in fetal liver and intestinal stem cells, finding higher mutation rates and distinct mutation spectra in fetal liver compared to fetal intestine and adult tissues.