PARP1 directly disassembles nucleosomes to regulate DNA repair
Ashish Verma, Changlei Zhu, Bernadette Truong, Silvija Bilokapić, Rebekah DeVries, Aaron Pitre, Anang A. Shelat, Mario Halić, Hai Thanh Dao
This study identifies PARP1's direct role in evicting histone dimers from nucleosomes to generate open chromatin intermediates that facilitate DNA repair.
bioRxiv · Mar 23, 2026 · PreprintMolecular Biology