Mario Halić

This study shows how transcription factor interactions enable binding to non-cognate DNA sites by bridging across nucleosomal DNA gyres.

This study identifies PARP1's direct role in evicting histone dimers from nucleosomes to generate open chromatin intermediates that facilitate DNA repair.

This paper investigates the G9a-GLP heterodimer's feedback mechanism, showing that both ANK domains are required for H3K9 dimethylation and nucleosome binding, suggesting intranucleosomal feedback.

The paper shows OCT4 binds to LIN28B nucleosomes assembled with human histones similarly to those assembled with Xenopus histones, using cryogenic electron microscopy.

The paper reports the cryoEM structure of (CENP-A/H4)2-di-tetramers on DNA and suggests their role as a platform for centromere organization through interactions with CCAN proteins.

This study uses cryo-EM to visualize how SNF2H, a chromatin remodeler, translocates DNA around the histone octamer by inducing conformational changes.

This study quantifies the contribution of transcriptional silencing and RNA degradation to heterochromatic silencing in fission yeast, revealing transcriptional efficiency as a new mechanism.

The paper shows that subtelomeric sequences in S. pombe are hyper-recombinogenic and have unstable nucleosomes, with Ccq1 protecting them through heterochromatic repression.