Bernard Y Kim

Inference of the distribution of selection coefficients for new nonsynonymous mutations using large samples

This study estimates the distribution of selection coefficients for new nonsynonymous mutations using large datasets, finding fewer strongly deleterious and more weakly deleterious mutations than previous estimates.

Determining the factors driving selective effects of new nonsynonymous mutations

The paper compares theoretical models of mutation effects and finds that Fisher's Geometrical Model best explains the distribution of fitness effects in humans compared to Drosophila melanogaster.