Divergence in poxvirus-encoded E3-like proteins can dictate poxvirus activation of cellular necroptosis
Junior A. Enow, Saige Munig, Mathew L. Sample, Gil Speyer, Raghavi C. Hundekar, Jacqueline Williams, James Bonner, Yize Li, Grant McFadden, Bertram Jacobs, Masmudur M. Rahman
This study identifies divergence in poxvirus E3-like proteins and shows that Leporipoxviruses induce necroptosis while Orthopoxviruses inhibit it.
Journal of Virology · Jun 17, 2026Peer-reviewedMicrobiology