Prenatal BRCA1 epimutations contribute significantly to triple-negative breast cancer development
Oleksii Nikolaienko, Hans Petter Eikesdal, Bjørnar Gilje, Steinar Lundgren, Egil Støre Blix, Helge Espelid, Jürgen Geisler, Stephanie Beate Geisler, Emiel A. M. Janssen, Synnøve Yndestad, Laura Minsaas, Beryl Leirvaag, Reidun Lillestøl, Stian Knappskog, Per Eystein Lønning
The paper identifies prenatal BRCA1 epimutations as a cause of approximately 20% of triple-negative breast cancers and low-ER expression breast cancers.
medRxiv · May 14, 2023 · PreprintGenetic & Genomic Medicine